Ask them where they go their loin clothes.

Dean

You called me Mary Campbell, do you know me?

Mary

Bobby: Who's the kid?
Jack: I'm Jack.
Mary: Friend of the family.
Bobby: That's good enough for me.

Some people just can't be saved.

Castiel

Dean: What's the last ingredient of this spell we're never going to find?
Sam: Blood of a most holy man.

The internet, you're not just for porn anymore.

Dean

Sam: So this is what we've come to? Thieves.
Dean: Hey, you want the blood, right?

Sam: Whack?
Dean: It's mob talk.

Technically the relic had a home, and then you had it stolen.

Dean

Sam: It's probably a dumbwaiter. All these old houses had them.
Dean: Know-it-all.
Sam: What?
Dean: What?
Sam: You said...
Dean: What?
Sam: Never mind.

Father Camilleri: God will see us through.
Dean: Yeah, he won't.
Father Camilleri: You're not a believer?
Dean: Oh, I believe. Hell, I know. God? He doesn't give a damn about you, or me, or anyone else. So if you're expecting some kind of miracle to happen, well, good luck.
Father Camilleri: I'm sorry. I didn't mean that God would reach down and protect us. Of course that's not going to happen, but I believe that all good things are God things. And what your brother's doing is a good thing.

Sam: You think we could every change things? I mean, really change things? You know, stop all the monsters, all the bad?
Dean: That would be nice.
Sam: Yeah. So what are you thinking? Think that'll work?
Dean: I have faith.

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean