I told you that roadhouse chili was a bad idea.

Sam

Game’s over, Dean. No more second chances. No more extra lives. Time to say bye bye to Luigi, Mario.

Billie

I'm going to come back for you. OK? I promise.

Dean

This is exactly how we screw ourselves. We make the heart choice instead of the smart choice.

Sam

Apparently archangel plus God power doesn’t trump God’s sister.

Sam

He who hesitates, disintegrates.

Lucifer

Sleeping is the new smoking.

Dean

Sam: Let’s pick up a six-pack.
Dean: Just six?

Last time I saw that look on an editor’s face, I’d just handed in "Bugs."

Chuck

You're wrong about humanity. They are your greatest creation because they're better than you are. Sure, they're weak, and they cheat and steal and destroy and disappoint, but they also give and create, and they sing and dance and love. Above all, they never give up.

Metatron

I didn't mean what I said about Supernatural. It's underrated, due for a reboot.

Metatron

Metatron: Why?
Chuck: Can you be more specific? I kind of get that question a lot about pretty much everything.

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean