Sam: Oh, d-dude... that's not what I think it is, is it?
Dean: I got bored. That nurse was hot.
Sam: You know you can go blind from that, too.

Dean: Yeah, everything Jesse believes comes true. He thinks the Tooth Fairy looks like Belushi, uh, joy buzzers really shock people, boom that's what happens.
Sam: Yeah, but convince him that joy buzzers don't actually work and they go from killer machines back into crap toys.
Dean: Probably doesn't even know he's doing it. How is he doing it?

Sam: Dude, what the hell?
Dean: I had a hunch I went with it.
Sam: You risked my ass on a hunch?
Dean: You're fine. Besides now we know who's turning this town into Willy Wonka's worst nightmare.

I'm Agent Bonham, this is Agent Copeland.

Dean

Dean: Not a word.
Sam: Dude, you just got whaled on by Paris Hilton.

Dean: Let me get this straight. Your, uh, ultimate hero was not only a short man in diapers, but he was a fruitarian.
Sam: That's not the point.
Dean: That is good. Even for you, that is good

Dean: Is that Gandhi?
Sam: Yeah!
Dean: Dude, he's squirelly.

Dean: Dude, he's short.
Sam: Hey, Gandhi was a great man.
Dean: For a Smurf.

Just when you thought you were out, they pull you back in, huh, Sammy?

Dean

Okay, so what, angels got their hands on some DeLoreans?

Dean

Sam: Thank you. Really. Thank you. I won't let you down.
Dean: Oh, I know it. I mean, you are the second-best hunter on the planet

Dean: I know what you are.
Lucifer/Sam: What am I?
Dean: You're the same thing, only bigger. The same brand of cockroach I've been squashing my whole life--an ugly, evil, belly-to-the-ground, supernatural piece of crap. The only difference between them and you is the size of your ego.
Lucifer/Sam: I like you, Dean.

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean