Hank Moody is a man with writer's block.
Living in California, following a move from New York City, he has trouble balancing all the factors in his life: there's his struggling career, his relationship with his daughter and ex-girlfriend and, of course, his desire for beautiful women. Many come and go from his bed.
Moody also enjoys his drinking and his drugging. Not that there's anything wrong with that.
Hank: Well the booze is always helpful and so is the art. Everything that I write is either for her or about her. So I'm with her, even when I'm not.