Lisa Marie Simpson, voiced by Yeardley Smith, is Homer and Marge's oldest duaghter and the middle child on The Simpsons.  Lisa is very intelligent, plays the saxophone, is a vegetarian, Buddhist, and definitely a bit of a young political activist.  She's basically the complete opposite of her brother, Bart.

Lisa Simpson Quotes

Lisa: Dad, I think he's an ivory dealer! His boots are ivory, his hat is ivory, and I'm pretty sure that check is ivory.
Homer: Lisa, a guy who's got lots of ivory is less likely to hurt Stampy than a guy whose ivory supplies are low.

Marge: It's your father, he's missing.
Bart: Dad's missing? Get outta here!
Marge: He's been gone for two days!
Lisa: What do you know, she's right!

The Simpsons Quotes

Homer: (Wearing glasses) The sum of the square roots of any two sides of an isosceles triangle is equal to the square root of the remaining side!
Man: (From inside a bathroom stall.) That's a right triangle, you idiot!
Homer: D'oh!

Wow, now I see why they call you Miss Hoover. You must have been vacuuming for an hour.