When Peter goes back in time and messes things up with Lois, she ends up marrying Quagmire and having a Chris, Meg and Stewie that look like Quagmire instead.
Aunt Margarite [on her video will]: Lois, you were always my favorite niece; I just knew you would find a wonderful man who would make all your dreams come true. But I was wrong. Peter: And now you're dead. Score one for Peter
