Mark and Callie

In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Callie and Mark share a moment outside the hospital. What's to come of these two?
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Patience with Patients

Meredith Grey monitors patients in this photo from the fourth season finale of Grey's Anatomy, "Freedom." She and Derek also must hash things out.
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Trials Continue

In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Meredith and Derek continue work on their clinical trial... and the trials of their own lives.
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Celebration?

In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Meredith is holding a bottle of what appears to be champagne. Think there's something to celebrate?
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Richard, Derek and Mark

In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Derek, Mark and Richard are seen in a rare scene outside Seattle Grace. Where is it?
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Grey, Meredith

In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Meredith Grey has some work to do... will this episode end with her and Derek together?
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That Derek Look

In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Derek gives Meredith that look he's known for. How can anyone possibly resist?
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Freedom

In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Meredith and Derek hash things out. Will Meredith achieve "freedom" from her demons?
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The MerDer Reunion

In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Meredith and Derek discuss their clinical trial... and figure out their lives. Hopefully.
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Izzie Gonna Listen?

In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Izzie is up in the face of Alex, ready to tell him how she feels. How will this end?
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Piece of Her Mind

In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Izzie is not about to take any more crap from Alex. This Rebecca stuff has gone on long enough.
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Now You Listen to Me!

In this photo from the fourth season finale of Grey's Anatomy, "Freedom," Izzie is not about to take crap from Alex. She's gonna stand up for what she wants.
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Grey's Anatomy Season 4 Episode 16 Quotes

Where have you been?! I've been waiting and waiting for you! And I did this stupid, embarrassing, humiliating, corny thing. And I was just gonna tell you that, this over here is our kitchen and this is our living room, and over there that's the room our kids could play. I had this whole thing about I was gonna build us a house, but I don't build houses because I'm a surgeon. And now I'm here feeling like a lame ass loser. I got all whole and healed and you don't show up. And now it's all ruined because you took so long to come home! And I couldn't even find that bottle of champagne ... (Derek holds up the bottle and smiles)

Meredith

Derek: Meredith....
Meredith: Stupid, corny, idiotic, I can't believe I did this. Stupid, loser, son of a ... I could be at home instead of ... oh
Derek: Meredith....