In many ways, this scene changed House history. Cuddy let our favorite doctor have it, and he responded with vulnerability never seen before.
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Can you ever reason with House? Foreman gives it a shot in the May 2010 season finale.
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House and Cuddy do have a lot to focus on during the season six finale. Including their relationship.
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In this scene from the House season finale, House and Foreman examine a victim. The episode is titled "Help Me" and originally airs on 5/17/10.
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House Season 6 Episode 21 Quotes

Is that a pill in your pocket, or are you just happy to have a tiny pill-shaped penis?

House

I'm the most screwed up person in the world.

House