In this episode still, House examines a patient (played by Sarah Wayne Callies) that has seemingly routine symptoms, yet leads an unorthodox lifestyle.
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House feels like a stranger in his own kitchen here. He's aghast at the relationship between Wilson and Sam.
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This is an awkward threesome. House stands around and joins Wilson and Sam for a discussion.
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Wilson and Sam discuss their relationship in this photo from the House episode "Open and Shut."
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Isn't this photo of Wilson and Sam adorable? No, not if you ask House.
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Sarah Wayne Callies guest stars on House on the 4/26/10 episode. It's titled "Open and Shut."
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House Season 6 Episode 18 Quotes

House, on a list of your attributes, there's nothing that even rhymes with coy.

Wilson

He's just trying to get into your skirts. And I don't mean metaphorically.

House