Even when Sam and Dean have tried to part ways they always find a way to continue fighting the good fight together. They really are destined to be the ones who try to save the world.
Dean made a deal with a crossroads demon in exchange for Sam's life. Dean's love for his brother knows no bounds and he wants to see his brother live his life.
A lot of people would cal Dean refusing to close the door to hell as selfish but Dean has never minced words when it comes to his brother. It's always just been Sam and Dean against the monsters of the world.
Dean first love is baby but he still took time to show Sam how to take care of her. Of course he was showing him how to fix her because he was going to be dying but you still have to appreciate Dean letting Sam have some control.
Sam and Dean are willing to work together on a multitude of cases but it's the various identities they have gone with over the years which makes them the best siblings on TV.
Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.