Sam and Dean are the two main reasons why Supernatural is such a hit. These two are great together.
Sam and Dean attend a fan convention on the episode "The Real Ghostbusters. An adventure ensues.
Seen here, in this scene from The Real Ghostbusters: Jensen Ackles as Dean and Jared Padalecki as Sam.
Sam is seen here at a Supernatual fan convention. The scene is from the episode "The Real Ghostbusters."

Supernatural Season 5 Episode 9 Quotes

Dean: Well, you sure look lovely tonight. Especially for a dead chick.
Latisha Actress: Buddy, I have heard that line 17 times tonight, okay? And all from dudes wearing MacGyver jackets. But you seem different.
Dean: How so?
Latisha Actress: Well, you don't seem scared of women.

Con Manager: Welcome to the first annual Supernatural convention. Uh, at 3:45 in the Magnolia Room we have the panel "Frightened Little Boy to Secret Life of Dean." And at 4:30, there's the "Homoerotic Subtext of Supernatural." And of course, the big hunt starts at 7 p.m. sharp.