When Homer's years of unhealthy eating catch up to him, he needs a triple bypass surgery.
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The Simpsons Season 4 Episode 11 Quotes

The knee bone's connected to the something. The something's connected to the red thing. The red thing's connected to my wrist watch... Uh oh.

Dr. Nick

Barney: If Homer wants to be a woman, so be it.
Homer: Barney, I'm not getting a sex change!