Amy: Should I go? I've been told, sometimes, I overstay my welcome.
Leonard: Wha ... who told you that?
Amy: Well, most recently my gynecologist.

Amy: If it makes you feel any better, the only person who signed my yearbook was my mother.
Leonard: Aww.
Amy: "Dear, Amy. Self-respect and a hymen are better than friends and fun. Love, Mom."

Penny: Wil Wheaton is Sheldon's mortal enemy.
Amy: Mortal enemy?
Penny: Mm-hmm.
Amy: Sheldon, I know you are a bit of a left-handed monkey wrench but... you really have a mortal enemy?
Sheldon: In fact, I have 61 of them.

Sheldon: This will just take a moment, it's on a five and a quarter inch floppy.
Amy: A floppy disk?
Sheldon: Well, I started the list when I was nine.

Amy: Sheldon, is it possible that your foul mood -- or, to use the clinical term, bitchiness -- is because your mother isn't making you a priority?
Sheldon: No. Or, to use the clinical term: "nuh-uh."

Sheldon, sometimes you forget, I'm a lady. And, with that comes an estrogen-fueled need to page through thick glossy magazines that make me hate my body.

Amy: At this moment, I find myself craving human intimacy and physical contact.
Sheldon: Oh, boy.

I'm just saying, second base is right there.

Whee! Ooh, finally someone found second base.

If you're keeping him, I've got a cage you can borrow. One of the test monkeys slipped on a banana peel and broke his neck. It was both tragic and hysterical.

Stuart: Can I help you find anything?
Amy: A comic that doesn't depict a woman whose bosom can't be used as a flotation device.

Amy: Sheldon, I am not going through menopause.
Sheldon: Are you sure? You said that with the testy bark of an old bitty.

TBBT Quotes

Oh, Bernadette, please play my clarinet.

Raj's poem

Sheldon: I'll have a diet Coke.
Penny: Can you please order a cocktail? I need to practice mixing drinks.
Sheldon: Fine... I'll have a virgin Cuba Libre.
Penny: That's... rum and Coke without the rum.
Sheldon: Yes, and would you make it diet?