DEREK: "Seattle has ferryboats?"
MEREDITH: "Yes."
DEREK: "I didn’t know that. I've been living here six weeks, and had no idea there were ferryboats."
MEREDITH: "Seattle is surrounded by water on three sides."
DEREK: "Hence the ferryboats. Now I have to like it here. I wasn’t planning on liking it here, since I'm from New York, and am genetically engineered to dislike everywhere except Manhattan. But I do have a thing for ferryboats."
MEREDITH: "I'm not going out with you."
DEREK: "Did I ask if you'll go with me? Do you want to go out with me?"
MEREDITH: "I'm not dating you and I'm definitely not sleeping with you again. You're my boss."
DEREK: "No, I'm your boss' boss."
MEREDITH: "You're my teacher and my teacher's teacher. And my teacher!"
DEREK: "I'm your sister. I'm your daughter."
MEREDITH: "You're sexually harassing me."
DEREK: "I'm just riding in an elevator."
MEREDITH: "Look, I'm drawing a line. The line is drawn. Thereis now a big line."
DEREK: "So this line... is it imaginary or do I need to get you a marker?"

Meredith: An hour and a half at the store to buy milk?
Derek: I think I might have closed my eyes in the store parking lot.

Always had to be the first.

Derek to Mark

He's perfect. He's just perfect.

MIRANDA: [steps in front of Derek] "No. Turn around and walk away."
DEREK: "From what?"
MIRANDA: "From my intern!"
DEREK: "No, I wasn’t going-"
MIRANDA: "Yes you were. Come on. You can’t do this. You don’t have the right. Not anymore."
DEREK: "I just want to find out if she's okay."
MIRANDA: "She's not. She's a human traffic accident, and everybody's slowing down to look at the wreckage. She's doing the best she can with what she has left, and I know you can't see this, 'cause you're in it, but you can't help her now! You'll only make it worse. So walk away. Go!"

He's hungry. My nipples are of no use to him.

[narrating] Yes or no. In or out. Up or down. Live or die. Hero or coward. Fight or give in. I'll say it again to make sure you hear me. The human life is made up of choices. Live or die. That's the important choice. And it's not always in our hands.

Meredith: You pulled a sleeping baby out of daycare to do your dirty work. You're disgusting!
Derek: He's got his mother's sparkle.

Anyone who's not surgically necessary is not welcome in my OR.

DEREK: "Maybe you should've thought of all this before you gave chief to Burke and invited Satan to Seattle."
RICHARD: "Satan?"
ADDISON: "Good morning Richard, like the hat."
DEREK: "Satan speaks."
ADDISON: "Actually, I prefer to be called ruler of all that is evil. But I will answer to Satan."

Derek: You are making this decision with Cristina.
Meredith: She's not the only factor.
Derek: You should be making this decision with me, your husband.

Derek: Hey. Come on in. This is a CT of Katie Bryce. 16 year old female, subarachnoid aneurysm.
Meredith: From a fall during rhythmic gymnastics. I remember.
Derek: I remember, it was the first surgery we ever scrubbed in together on. Our first save. Right here is a cerebral cyst. Tough save, but we did it. I kissed you in the stairwell after the surgery. And this right here is where Dr Bailey kicked you out of the surgery, because she caught us in your driveway, in my car. And right here, this is a seven hour craniotomy. You held the clamp the entire time, never flinched. That's when I knew you were gonna be an incredible surgeon. Beth Monroe, made our clinical trial a success by surviving. You talked me into putting her under. That's when I knew I needed you. And this is today, post op head CT of Izzie Stevens. You see that? Right there. Tumor free. Because of you. You got me into the OR. If there's a crisis, you don't freeze, you move forward. You get the rest of us to move forward. Because you've seen worse. You've survived worse, and you know we'll survive too. You say you're all dark and twisty. It's not a flaw, it's a strength. It makes you who you are. I'm not gonna get down on one knee, I'm not gonna ask a question. I love you Meredith Grey, and I wanna spend the rest of my life, with you.
Meredith: And I wanna spend the rest of my life with you.

Grey's Anatomy Quotes

When we say things like "people don't change" it drives scientist crazy because change is literally the only constant in all of science. Energy. Matter. It's always changing, morphing, merging, growing, dying. It's the way people try not to change that's unnatural. The way we cling to what things were instead of letting things be what they are. The way we cling to old memories instead of forming new ones. The way we insist on believing despite every scientific indication that anything in this lifetime is permanent. Change is constant. How we experience change that's up to us. It can feel like death or it can feel like a second chance at life. If we open our fingers, loosen our grips, go with it, it can feel like pure adrenaline. Like at any moment we can have another chance at life. Like at any moment, we can be born all over again.

Meredith

Callie: Did anyone ever think you two were a couple?
Meredith: No, because we screw boys like whores on tequila.
Cristina: Then we either try to marry them or drown ourselves.
Callie: Huh.