Anyone who's not surgically necessary is not welcome in my OR.

I just got Zola her first fishing pole. It's pink.

I will be Derek Shepherd, the former neurosurgeon who is now a research librarian.

Meredith, I'm alive. We survived. Zola has us both for parents. That's enough.

Always had to be the first.

Derek to Mark

Cristina: What's the t-shirt for?
Derek: I'm going to scream alot, probably pass out.

Mark can buy it. His dreams have always been my dreams.

How's Julia? You impregnate her yet?

Derek: You are making this decision with Cristina.
Meredith: She's not the only factor.
Derek: You should be making this decision with me, your husband.

Meredith: We're staying.
Derek: We're going.

When did I become the advice columnist?

He's happy with the eyeball doctor. So make sure you want him because you want him and not because he's with someone else.

Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

I want to marry you. I want to have kids with you. I want to build us a house. I want to settle down and grow old with you. I want to die when I'm 110 years old, in your arms. I don't want 48 uninterrupted hours. I want a lifetime. Mmm. Do you see what happens? I say things like that and you fight the urge to run in the opposite direction. It's okay, I understand. I didn't, but now I do, I do. You're just getting started and I've been doing this for a long time now. Deep down, you're still an intern, and you're not ready.

Derek