I will be Derek Shepherd, the former neurosurgeon who is now a research librarian.

Meredith, I'm alive. We survived. Zola has us both for parents. That's enough.

Always had to be the first.

Derek to Mark

Cristina: What's the t-shirt for?
Derek: I'm going to scream alot, probably pass out.

Mark can buy it. His dreams have always been my dreams.

How's Julia? You impregnate her yet?

Derek: You are making this decision with Cristina.
Meredith: She's not the only factor.
Derek: You should be making this decision with me, your husband.

Meredith: We're staying.
Derek: We're going.

When did I become the advice columnist?

He's happy with the eyeball doctor. So make sure you want him because you want him and not because he's with someone else.

Derek: Come back to me.
Meredith: What's to miss in Neuro?
Derek: Me.

You are so sexy when you are looking at a teratoma.

Grey's Anatomy Quotes

Amelia: I think I'm falling in love with Owen Hunt, and I'm really afraid that it's gonna destroy me.
Derek: It wouldn't be love if it didn't.

I want to marry you. I want to have kids with you. I want to build us a house. I want to settle down and grow old with you. I want to die when I'm 110 years old, in your arms. I don't want 48 uninterrupted hours. I want a lifetime. Mmm. Do you see what happens? I say things like that and you fight the urge to run in the opposite direction. It's okay, I understand. I didn't, but now I do, I do. You're just getting started and I've been doing this for a long time now. Deep down, you're still an intern, and you're not ready.

Derek