Howard: Son of a bitch, she's gone.
Bernadette: Where'd she go?
Howard: I don't know. She didn't leave a note.
Bernadette: You were the one who was supposed to put her back in the stroller!
Howard: No, I wasn't! You were!
Bernadette: No, I wasn't!
Howard: Yes, you were!
Bernadette: Well, you throw like a girl.

Howard: When this all blows over, remember that voice. It's kind of a turn-on.
Bernadette: It turns you on when I sound like Raj?

And, space beats water.

Howard: There's a party for incoming post-docs tonight. Go to it and meet someone who isn't made of grease or pie.
Raj: You think you're so cool because your wife is a person?

Penny [on phone]: How about this, you keep him there a little longer, and when you get to the party, I'll point out which of my friends are easy.
Wolowitz: ... Don't toy with me, woman.
Penny: I got a hot former fat girl with no self-esteem, I got a girl who punishes her father by sleeping around, and an alcoholic who's two tequila shots away from letting you wear her like a hat.
Wolowitz: Thy will be done

Hey, easy. My nipples are sensitive.

Howard: No, I am definitely up a cup size.
Raj: You, know, b-but they're very firm, so you've got that going for you.
Howard: You think?
Raj: Yeah. Yeah. Yeah. Very perky.
Howard: Thank you. I really needed to hear that today.

Sheldon: I propose we add "pants must be worn at all times in the time machine"
Leonard: Seconded.
Wolowitz: I was gonna put down a towel

Howard: Can you imagine seeing someone all day long and then you're supposed to hang out with them after work, too?
Raj: Hold on. We do that all the time. You and I work together and play together.
Howard: Yeah, I know, and it drove me into the arms of another woman.

Wolowitz: Don't you think I should answer the engineering question? I am an engineer.
Sheldon: By that logic I should answer all the anthropology questions because I'm a mammal

Sheldon: Am I wasting my life on a theory that can never be proven?
Howard: Maybe. But how great is Game of Thrones?

Sheldon: 15 years old. Dennis Kim is 15 years old and he's already correcting my work. Today I went from being Wolfgang Amadeus Mozart to—you know—that other guy.
Wolowitz: Antonio Salieri.
Sheldon: Oh, God, now even you're smarter than me.

TBBT Quotes

Oh, Bernadette, please play my clarinet.

Raj's poem

Sheldon: I'll have a diet Coke.
Penny: Can you please order a cocktail? I need to practice mixing drinks.
Sheldon: Fine... I'll have a virgin Cuba Libre.
Penny: That's... rum and Coke without the rum.
Sheldon: Yes, and would you make it diet?