Derek: That's my chair.
Mark: I know I like it. Makes me feel powerful.

[lying with Callie and Arizona] This isn't gonna work for me ...

[to Callie] You're MY friend, not hers. Don't you take her side!

[to Lexie] I can't even look at you right now.

Mark: Don't make me choose between you are her.
Lexie: Why? Because you'll choose her?
Mark: Yeah. I'll choose her.
Lexie: I think our relationship just ended.

Because of you, for the first time in my life, I know what the right thing is.

I know I've only been your father for a short time, but I swear, if you say gimp one more time, I'm gonna slap you.

Addison: You told her?
Mark: She's my kid. We were bonding.
Addison: That's now how you bond with children.
Mark: I'm still getting the hang of it.

Addison: Let me say it once: Grandpa... Grandpa, grandpa, grandpa!
Mark: Okay. That was four times. Get it out of your system?

Get me Addison Montgomery!

I'm a surgeon and I'm looking at a time bomb in a uterus. Shut it down now, Addison!

Mark: It's the guilt, you know? It's like every time I look at her... I just... The guilt is like a punch in the gut. Everyday.
Derek: Well, you shouldn't feel guilty, you didn't know.
Mark: I did know. I knew it when her mom got pregnant. She told me. I gave her a couple hundred bucks and I left town and I never saw her again. I figured she got an abortion. Hoped. But I did know.
Derek: Well you're a different guy now. You're not 18 anymore, you've grown up, and you're capable of better.

Grey's Anatomy Quotes

Meredith: You're me.
Amelia: What?
Meredith: You're me before Derek. I can be here for you. I can do this. I get you. I can be a twisted sister for you. Just tell me how do you want to play this?

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)