Derek: That's my chair.
Mark: I know I like it. Makes me feel powerful.

[lying with Callie and Arizona] This isn't gonna work for me ...

[to Callie] You're MY friend, not hers. Don't you take her side!

[to Lexie] I can't even look at you right now.

Mark: Don't make me choose between you are her.
Lexie: Why? Because you'll choose her?
Mark: Yeah. I'll choose her.
Lexie: I think our relationship just ended.

Because of you, for the first time in my life, I know what the right thing is.

I know I've only been your father for a short time, but I swear, if you say gimp one more time, I'm gonna slap you.

Addison: You told her?
Mark: She's my kid. We were bonding.
Addison: That's now how you bond with children.
Mark: I'm still getting the hang of it.

Addison: Let me say it once: Grandpa... Grandpa, grandpa, grandpa!
Mark: Okay. That was four times. Get it out of your system?

Get me Addison Montgomery!

I'm a surgeon and I'm looking at a time bomb in a uterus. Shut it down now, Addison!

Mark: It's the guilt, you know? It's like every time I look at her... I just... The guilt is like a punch in the gut. Everyday.
Derek: Well, you shouldn't feel guilty, you didn't know.
Mark: I did know. I knew it when her mom got pregnant. She told me. I gave her a couple hundred bucks and I left town and I never saw her again. I figured she got an abortion. Hoped. But I did know.
Derek: Well you're a different guy now. You're not 18 anymore, you've grown up, and you're capable of better.

Grey's Anatomy Quotes

It's harder to love somebody than to walk away from them.

Amelia

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."