Penny: See, this is why I've been saying we should keep champagne on ice.
Sheldon: Sarcasm?
Amy: Yes.
Sheldon: That was tricky because when it comes to alcohol she generally means business.

Leonard: I'm telling you, you can't create love in a few hours. Right?
Penny: Careful. You're poking at the whole foundation of The Bachelor.

Sheldon: When I lost my father, I didn't have any friends to help me through it. You do.
Penny: I really thought he was going to say, "Let it go."

Penny: I don't want five dollars. I want my dignity.
Amy: So what are we talking about? Ten bucks?

Oh, hey! Did you see that? I figured out how to open my door all by myself. Maybe I'll fling some feces around my cage to celebrate.

Sheldon: Gee, Penny. Life's given me lemons, what should I do?
Penny: You could shove them somewhere.
Sheldon: Okay, now you're getting creative.

Amy: Okay, that's enough.
Penny: What? No! I really want to know what happens-- and Bernadette really, really, really wants to know what happens.

Penny reading Amy's book: "Amelia stood before the newly repaired time machine.She regretted giving Cooper the part he needed."
Bernadette: Because she wanted him to give her the part she needed.

Penny: You look like a talking cupcake!
Pageant Bernadette: And you should pick me for Miss California Quiznos 1999, because I want to...Tell you what I want, what I really really want I'll tell you what I want, what I really really want I wanna, I wanna, I wanna, I wanna Really, really, really be Miss California Quiznos 1999!

Leonard: This... is exciting. This is really exciting. I have to go find Sheldon.
Penny: Okay, well, if you find him, use the kitchen island- that coffee table will not support both of you.

Penny: Yeah, I listen to what you say. You're building a particle detector using superfluid helium.
Leonard: You know, when you talk like that, I want to take you right here on this table.
Penny: And you know from past experience this table cannot support both our weight.

Penny: Sheldon, we are just people. we talk about the same things you guys talk about.
Sheldon: You talk about if werewolves can swim?

TBBT Quotes

Sheldon [to Kripke]: Also, I am given to understand that your mother is overweight.
Raj: Oh, snap.
Sheldon: Now of course, if that is the result of a glandular condition and not sloth and gluttony then I withdraw that comment.

How is "doable" anything but a compliment?

Wolowitz