Serena: You know, I don't know why I ever had a crush on you.
Julian: Serena, I'm gay.

Serena: You know maybe I should be the one to tell Dan what's going on. At least he considers me a friend, which is more than you can say right now.
Vanessa: And who's fault is that?
Serena: Yours.

Ben: What about your family? What if us being together drives them all away?
Serena: I don't think it will but that's a risk I'm willing to take if you are.

Tripp: I did want you here. I find you smart and charming, and I wanted to help you out. But having you here ... I didn't realize how much it would effect me. Say something.
Serena: You know what? Don't worry about me. It's not going to be a problem.

Serena: Like when she married a raging cokehead that left blow everywhere?
Eric: It wasn't everywhere. Just on the smooth, shiny surfaces.

Serena: And you really expect me to believe this isn't all about revenge on Chuck?
Blair: Revenge is so 12 hours ago!

Serena: We have her.
Chuck: You want to make the call or should I?
Serena: No. Later. In person.
Chuck: I like the way you think, mom.

Serena: So Mr. Screenwriter, are you ready for your first development meeting?
Dan: I think so. As long as you guys don't want to change the ending. Or the beginning. Or all the stuff in the middle.

Damien: I don't give anyone anything that they don't come looking for.
Serena: Okay, well then I guess you're only half responsible that I almost died.

She wants you all to think she's the perfect host and mother and wife, but the truth is she's a selfish liar who will destroy anyone that gets in her way.

Serena: Chuck, you might want to try to stop the police.
Chuck: Why would I stop them? I called them.

Aaron: Do you know how to weld?
Serena: Um, I've seen Flashdance several times?

Gossip Girl Quotes

Even Blair Waldorf can not bend DNA to her will.

Dan

Hazel: Do you know what you're doing, Little J?
Jenny: I'm not Little J anymore.