Diana: Jane and I have history. She doesn't always like to be reminded of it, but it's been awhile since I did.
Serena: What kind of history?
Diana: Some things are best left to the imagination. So, how bad do you want your problem to go away?

Serena: Because, I would rather Dan think I cheated on him than know what I really did.
Nate: What you really did?

Serena: B, can I talk to you for a minute?
Blair: Yes. [to Minion #1] Five paces behind. For privacy. [to Minion #2] Ten for you.

[to Chuck] You're not going to find anything in there.

Serena: I hear the Ice Capades are coming to town.
Dan: If you're there, so am I.

I killed someone.

Just because he took all the money doesn't mean our feelings weren't real.

Eric: I mean, people thought that I was Gossip Girl.
Serena: [laughs] You have to admit, it made sense at the time.

Don't you see, Dan? The Blair that you're in love with isn't the real Blair. It's the one you created in your book. And she's always loved Chuck. She just used you to get between us because she knew that I loved you.

Serena: Blair? What is going on?
Blair: This is Amanda. She'll be joining us for lunch.
Serena: Blair.
Blair: It's for your own good, S. They were going to lunch together. Lunch! As in the meal before dating? Is that what you want, S?

Serena: So where's Georgina?
Chuck: You're out of luck, she just left.
Serena: Where's Dan?
Chuck: I'm out of luck, he's still here.

[to Rufus] You know you're more scared of my mother than I am?

Gossip Girl Quotes

Even Blair Waldorf can not bend DNA to her will.

Dan

Hazel: Do you know what you're doing, Little J?
Jenny: I'm not Little J anymore.