Penny: That's thinking ahead.
Sheldon: The alternative would be to think backwards.. and that's just remembering.

It did not kill me when you went to space. Monkeys went to space.

I have to say I thought the toilet humor would get less funny with repetition. Apparently there is no law of diminished comedic returns when it comes to space poop

Sheldon: How could you not find him?
Leonard: Because he's hard to find. If he was easy to find, the books would be called "There's Waldo."

[Sheldon karate chops Leonard in the shoulder]
Leonard: Ow! Why did you do that?
Sheldon: To send a message: she's not for you!
Leonard: What?
Sheldon: Not for you!

It is to viagra as viagra is to a green M&M.

They can't just cancel a show like Alphas. You know? They have to help the viewers let go. Firefly did a movie to wrap things up. Buffy the Vampire Slayer continued on as a comic book. Heroes gradually lowered the quality season by season till we were grateful it ended.

Oh, no. They sent the wrong Spock. Live long and suck it, Zachary Quinto.

Leonard: What are you doing?
Amy: We're playing doctor. Star Trek style.
Sheldon: I'm in hell, Leonard. Don't stop.

Leonard: Why do I have to talk to Penny? She's not my girlfriend.
Sheldon: You invited her to lunch four years ago, everything about her is on you: you make it so!

Penny: I'm a vegetarian. Well, except for fish, and the occasional steak. I love steak!
Sheldon: Well, that's interesting. Leonard can't process corn

Sheldon: I can't seem to get in touch with Amy. I tried e-mail, video chat, tweeting her, posting on her Facebook wall,texting her, nothing.
Leonard: Did you try calling her on the telephone?
Sheldon: The telephone. You know, Leonard, in your own simple way, you may be the wisest of us all.

TBBT Quotes

Oh, Bernadette, please play my clarinet.

Raj's poem

Sheldon: I'll have a diet Coke.
Penny: Can you please order a cocktail? I need to practice mixing drinks.
Sheldon: Fine... I'll have a virgin Cuba Libre.
Penny: That's... rum and Coke without the rum.
Sheldon: Yes, and would you make it diet?