Sheldon: Lipid residue. An anal autograph. A colon calling card, if you will.
Cleaner: Tuesday okay?

Please tell me you are not having coitus.

Sheldon: It's doubtful that his mother will be over-impressed with a woman whose biggest achievement was memorizing the Cheesecake Factory menu.
Penny: Hey, it's a big menu! There's two pages just for desserts!
Leonard: And those specials, they change every day!
Penny: Okay, it's lame when I say it, it's just ridiculous when you pile it on.

Was the starfish wearing boxer shorts? Because I'm pretty sure you were watching Nickelodeon.

Amy: This year's donations may go to, say, the geology department.
Sheldon: Oh dear, not the dirt people.

There's always a chance that alcohol and poor judgment on her part may lead to a wonderful evening

Jeepers! That's yucky.

Penny: Where are you going?
Sheldon: Where ever the music takes me kitten.

Sheldon: Is the whip sound app contextually appropriate here?
Leonard: Uh, it is, but I think you might have waited too long for it to be funny.
[whip cracks]
Leonard: [Everyone laughs] I was wrong; it was still funny.

Sheldon: Now, back to our game.
Raj: You were in the middle of an erection.
Sheldon: Oh, of course. It's right here in my hand.

Howard: No ... about my job. I want you to tell me I'm good at what I do.
Sheldon: You're obviously good at what you do.
Howard: Well, then why are you always ripping on me?
Sheldon: Oh, I understand the confusion. I have never said that you are not good at what you do, it's just that what you do is not worth doing.

I have a lady friend who will be staying with me for a few days. I want her to feel at home; I also bought scented soaps, pantyhose, Midol, calcium chews, and what is apparently a yogurt specifically designed to regulate the female bowel.

TBBT Quotes

Oh, Bernadette, please play my clarinet.

Raj's poem

Sheldon: I'll have a diet Coke.
Penny: Can you please order a cocktail? I need to practice mixing drinks.
Sheldon: Fine... I'll have a virgin Cuba Libre.
Penny: That's... rum and Coke without the rum.
Sheldon: Yes, and would you make it diet?