Susan: So, you're trying to tell me that it is random.
Roy: I'm trying to do anything I can to get you to stop crying, honey. You're on a lucky street. Who knows why? Just enjoy it.
Susan: But, what happens when my luck runs out? I know - Why ask?
Roy: Why ask?

Susan: Look at me! I should buy a lottery ticket right now.
Bree: Yes, you should. Then, you should "eat it!"

Mike: You're dying, and there's not a damn thing I can do about it. Like I'm sorry, but it feels like you're getting ready to say goodbye like you're bailing on me.
Susan: Bailing? I am fighting. I am scared. I don't know what's going to happen but I am fighting my ass off. I want to see MJ graduate. I want to grow old with you, and I want all of that. But in the meantime, I'm going to enjoy every moment of every day.
Mike: Let's get out of here.
Susan: Hey. Lean on me. I'm a lot stronger than you think.

Renee: And that is how you get out of paying for a taxi!
Susan: Well, we weren't in a taxi - we were in my car. But now I know why you showed me your boobs.

How come you never told us you were sleeping with Tommy Tripod?

Gaby: Remember when you and I had dinner with that French guy?
Susan: The guy you referred to as "Le Package?"

If you don't get out of my face, I'm gonna ram this Thigh Master down your throat.

Do you feel betrayed, humiliated? Good! Because I only did this to show you what it feels like when the person that's supposed to love you the most lies to you.

Come on, this is my chance! My aunt had a stroke while driving. When am I gonna get that lucky again?!?

This is my turn to flaunt. And I can't flaunt with a free piano.

Mike: Why is there a big ass piano in our house?
Susan: Actually, Big Ass stopped making pianos. This is a Yamaha.

I have an expensive, worthless art degree that says I know what I'm talking about.

Desperate Housewives Quotes

Dr. Barr: Hey there. I was surprised to hear you wanted a session.
Bree: Well, there's nothing like being tied to a bed to change a girl's mind.
Dr. Barr: What do you wanna talk about?
Bree: Anything at all. As you said, I...I have a lot of issues.
Dr. Barr: Well, I assumed as much when you told the ridiculous story about your daughter running off with a murderer.
Bree: Saw right through that, did ya?
Dr. Barr: Well, I'm a trained professional, Bree. The human mind is my playground.
Bree: Well, I'm glad that you're having fun.

(to dead body) "Tu me manques, Monique" ("I Miss You Monique").

Orson