Serena: I'm here on a rather pathetic mission. I'm boyfriend snooping.
Vanessa: I see.
Serena: It's not something I'm proud of, but I don't know what else to do. Something's going on with Dan, I thought I knew what it was but I don't. I was wondering if he said anything to you.
Vanessa: No he didn't. I'm sorry.

Vanessa: Serena, I know you like him, but as your friend, Julian is the most self-absorbed pompous person I have ever met. All he does is go on and on about classic movies and it's totally annoying.
Serena: You were keeping up with him pretty good there.
Vanessa: Yeah. And I'm totally annoying.

I came to you because I wanted to do something besides feel sorry for myself, but all it's been has been sleazy platitudes and you staring at my boobs.

[to Nate, about Chuck] We're not a couple, it's just physical.

Chuck: I came up with several excellent ideas. You just shot them down.
Vanessa: Yeah, because most of them involved leaking the Chuck-Vanessa sex tape on the Internet.
Chuck: We don't have to leak the tape if you don't want to.

[playing 'I Never'] I never slept with Chuck Bass. [drinks]

[still playing 'I Never'] I never slept with Chuck Bass twice. [drinks faster]

Vanessa: [kisses Scott] I think we've done enough talking for one night. And I thought one of us should finally make the first move.
Scott: I'm glad you did.

Dan: Please, please, give me a break with the rich-people-suck thing.
Vanessa: I don't care if you're rich - which you are, by the way - but if you're going to live in that world, be yourself in that world.

[on the polo match] I'm sure Blair and Chuck will be there, if the murder-suicide I've predicted hasn't happened yet.

Even Frodo eventually gave in to the power of the Ring.

Rufus: Does this place actually serve coffee, or what?
Vanessa: Yes, it does!

Gossip Girl Quotes

Even Blair Waldorf can not bend DNA to her will.

Dan

Hazel: Do you know what you're doing, Little J?
Jenny: I'm not Little J anymore.