Please just sit down with him. Coulson, he's a good man. He's the only person who's ever tried to take care of me. And until now he's the closest I've had to family.

Skye

Skye: You knew, didn't you? Your visions, you saw fire, destruction. You knew it would all fall apart.
Raina: I'm afraid so. Everyone thinks flowers are so delicate, but they really are quite resilient.
Skye: I'm not here to talk botany.
Raina: No, you're here to ask questions about what's going to happen next.
Skye: Yes.
Raina: Well that's the tragedy, because even if I were inclined to tell you... you wouldn't believe me.

Skye: She knew I would see this. She said as much. She saw who you really are so you killed her.
Jiaying: Everything I've done, everything I will do is for the protection of our people.
Skye: You killed Gonzales. You want a war.
Jiaying: War was inevitable. I struck first so we would have the advantage.
Skye: He came to make peace.

Simmons: You'll be careful.
Fitz: I won't be careful, I'll get the job done.
Simmons: Well, watch your back because I just saw Hunter with Bobbi and it made me realize that... It's just that, we never really spoke about what you said to me at the bottom of the ocean.
Fitz: This? Now? You want to talk about this now?
Simmons: No, we don't... it means a lot to me that we're friends again and maybe when you get back we could finally just talk about it.
Fitz: There's nothing to discuss Jemma.
Simmons: Maybe there is.

Cal: I reassembled her, piece by piece; sewed her back up. But she was never the same.
Coulson: She was out for blood.
Cal: Before Whitehall, an elder would sacrifice themselves every few decades so she could live on; carry on tradition. She would weep, scream, beg them not to. She had a good heart Phil, she did. It was just torn out.

Coulson: Are you ready to refocus your energies?
Skye: Team centered around people with powers? How many on the list?
Coulson: Right now, just you. Take it slow.

Daisy: We try to protect people like you from the world, or from yourself. Unless we have to defend the world against you.
Joey: People like me? What is happening to me?
Daisy: You've experienced what's called a biomorphic event. Short version, your DNA changed.

Mack: We lost Fitz again huh? He out there chasing down another ghost story?
Bobbi: He has a theory.
Mack: He's always got a new theory. That's why he locked up that damn rock and won't let anyone in.
Bobbi: He wouldn't dare go in there. He's not totally irrational. The process of digging just helps him cope.
Mack: No, it keeps him from coping. Look, I love the fact that he won't give up hope. I do. But the man's a scientist and the evidence is pointing one way.

Rosalind: These altered humans are a threat and I'm in charge of neutralizing that threat.
Coulson: By any means necessary, sounds like is coming next. And who do you answer to?
Rosalind: Mr. Coulson, it's others who answer to me. The laws of nature have changed, and until the laws of man change to reflect that we can only do what we feel is right.
Coulson: I agree. I think.

Coulson: Daisy damn it, hard for us to get used to, huh?
Mack/Hunter: Ah, no, just you.

You have shown so much heart never giving up on Simmons, and I will always respect you for it. But look around, we need you. We need that big brain of yours and that heart here.

Coulson

Hill: What does S.H.I.E.L.D. stand for Agent Ward?
Ward: Strategic Homeland Intervention, Enforcement and Logistics Division.
Hill: And what does that mean to you?
Ward: That someone really wanted our initials to spell SHIELD.

Agents of S.H.I.E.L.D. Quotes

Kasius: Yo-Yo Rodriguez? How peculiar.
Yo-Yo: Says the space mime!

Sousa: Hey, what are you doing up?
Daisy: Why do you care?
Sousa: Because you don't.