Ria: When a person's facial expression is not symmetrical across their face, it is likely that they are pretending to feel the emotion. From your article in The Journal of Behavioral Science, 2001.
Cal: Sucking up's not your strong suit, is it?

Russian spies? Oh what's next? Duran Duran? Parachute pants? Because I love the eighties.

Eli

Farida: Do you bring all your dates here?
Eli: Just the Ugandan peace activists.

Hughs: It's been two hours. You think we can trust that pervert?
Cal: Yeah. In my experience, self-castrating pedophiles generally tell the truth.

(to Gillian) You know, you were very good back there, with Mrs. Burch. Very nurturing. Maybe you should get a puppy. I could talk to Obama's people.

Cal

Eli: She wanted to sign my book. I think we had a connection.
Ria: Oh yeah. I guess Ugandan women can't resist a guy with a girly drink.

Ria: You have an incredible story.
Farida: Thank you.
Ria: I mean, everything you've done.
Eli: Changing the world through peaceful resistance. You're like Gandhi. Except you don't look like a malnourished old man.
Farida: You're too kind.

Here's the problem, Martin Walker is a psychopath and probably a killer. Just though you should know.

Cal Lightman

Ria Torres: You really want to take this case?
Eli Loker: What, is the guy and eccentric? Yes, big time. But so am I, have you seen this shirt.

Martin Walker: A good chess player thinks five moves ahead.
Cal Lightman: Great chess players only think one move ahead, but it's always the right move.

Ria Torres: Must be hard to be somewhere 30 years and trying to make sense of all of this.
Sam Hendricks: What's hard is they confuse growing old with growing stale.

Gillian: Do you still have that note, that I brought you? I want it for my office.
Cal: (handing over the note) You really are a pack rat.
Gillian: You could have just told me what this was for.
Cal: No. You're a terrible liar.
Gillian: Normal people think that's a good thing.

Lie to Me Quotes

Weil: You haven't done enough muck-raking for one day?
Ria: Sir. We don't think you were doing anything sexual at that club, because, I believe this escort, Melissa, who you paid for time with-
Weil: What about her?
Ria: She's your daughter.

Gillian: Do you still have that note, that I brought you? I want it for my office.
Cal: (handing over the note) You really are a pack rat.
Gillian: You could have just told me what this was for.
Cal: No. You're a terrible liar.
Gillian: Normal people think that's a good thing.