Mrs. Holden is uh, Mrs. Holden decided that the life we created together was no longer enough so she has left in search of greener pastures.

Bill

Some men come home to fame and fortune, some to measure ejaculate.

Lester

I didn't see her coming. I'm always so careful, you know, with people. She's my friend and I don't have a lot of those.

Virginia

I don't know how to not fight.

Virginia

You're staring at them. Like some Peeping Tom.

Bill [to Libby]

I'm yours and you're mine. That's enough for me.

Gene [to Betty]

Your lack of interest is rather liberating actually. I could likely say anything to you and you wouldn't blink. I was raised by vampires! I drive getaway cars in my spare time! I once had intercourse with a corpse!

DePaul

You are not coming back into my life after the hell it took to get you out.

Betty

Try not to perpetuate the sick belief that women need to open their legs to get a leg up!

DePaul [to Virginia]

Bill: I don't Lillian regards you quite as highly as you think.
Virginia: Why would you say that?
Bill: She knows about us. About the work we're doing...upstairs.

He's not just rolling downhill Ginny, I mean he's picking up speed.

Libby

We don’t look the same but we are the same. We are not men who wait. You need to make a case for yourself, you need to call every patient you ever had and say this is where you need to be with me, at this hospital. That’s how you move your practice forward. That's how i move this hospital forward. That's how we move history forward.

Charles [to Bill]

Masters of Sex Quotes

I think women often confuse love with physical attraction.

Virginia

Women fake orgasms, maybe all of em. Although I haven't checked my clipboard lately

Betty