It's very simple. Scissors cuts paper, paper covers rock, rock crushes lizard, lizard poisons Spock, Spock smashes scissors, scissors decapitates lizard, lizard eats paper, paper disproves Spock, Spock vaporizes rock, and, as it always has, rock crushes scissors

Sheldon

Amy: Jewelry? Seriously? Sheldon, you are the most shallow, self-centered person I have ever met. Do you really think that another transparently manipul... Oh! It's a tiara! A tiara. I have a tiara! Put it on me, put it on me, put it on me, put it on me, put it on me, put it on me, put it on me.
Penny: You look beautiful
Amy: Of course I do. I'm a princess and this is my tiara.
Sheldon: You were right, the tiara was too much.

Leonard: Have you considered telling her your feelings?
Sheldon: Leonard, I'm a physicist, not a hippie.
Leonard: Well let me see if I can explain your situation using physics. What would you be if you were attached to another object by an incline plane, wrapped helicly around an axis.
Sheldon: Screwed.
Leonard: There you go.

Go away! She wants New Delhi, not Kosher Deli!

Raj

Would you like some aloe vera? You just got burned.

Sheldon

Raj: We'd just see what's what.
Sheldon: That's a semantically null sentence.

Penny: Not knowing's part of the fun.
Sheldon: Was that the motto of your community college?

I do not have to urinate. I am a master of my own bladder. Drat.

Sheldon

No, Gorn, no! That's where I sit.

Sheldon

Amy: When you told me I was going to be "losing my virginity," I didn't think you meant you'd be showing me Raiders of the Lost Ark for the first time.
Sheldon: My apologies. I chose my words poorly. I should have said you were about to have your world rocked on my couch.

It's like we both had these holes in our lives, but now we fill each other's holes.

Raj

Wil [about Sheldon]: Did that guy just say, "revenge is a dish best served cold" in Klingon?
Stuart: I believe so
Wil: What is wrong with him?
Stuart: Everyone has a different theory

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TBBT Quotes

Oh, Bernadette, please play my clarinet.

Raj's poem

Sheldon: I'll have a diet Coke.
Penny: Can you please order a cocktail? I need to practice mixing drinks.
Sheldon: Fine... I'll have a virgin Cuba Libre.
Penny: That's... rum and Coke without the rum.
Sheldon: Yes, and would you make it diet?