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IZZIE: "Take off your pants."
ALEX: "Izzie, what are you doing?"
IZZIE: "I'm being a doer. Getting while the getting's good. Now take off your pants."
ALEX: "You realize when I said the apocalypse before, I meant it metaphorically, not literally."
IZZIE: "Alex, I haven't had sex in eight months and 12 days. I'm horny, I'm half-naked, and I'm saying yes. Do you want to stand there and talk metaphors, or do you want to literally take off your pants?"