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Izzie: Thought you were sleeping with Michelle tonight. Or was it Jackie?
Alex: Izz ...
Izzie: I've had a hard day Alex. Would you please just leave me alone?
Alex: Izzie ...
Alex: I'm not good at this. I'm not good at ... relationships or talking about stupid feelings. And you are, so maybe you could teach me or something. Tell me where I go wrong.
Izzie: [pauses] You don't want us to see other people. You don't want us to see other people and that's how you tried to tell me! [laughs] By asking if it was cool if you screw Michelle.