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Dean and Bobby lock Sam in Bobby's panic room in order to let him detox from demon blood.  But as Bobby sees more seals being broken, he wants to let Sam out to help them stop the apocalypse.  Dean disagrees and goes to Castiel for help.  Sam and Dean fight.

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Supernatural Season 4 Episode 21 Quotes

Dean: How long is this gonna go on?
Bobby: Here, let me look it up in my demon-detox manual. Oh, wait. No one ever wrote one.

Congrats, Sammy. You just bought yourself a benchwarmer seat to the Apocalypse.