Homer Simpson, voiced by Dan Castellaneta, is the patriarch of The Simpsons and is definitely the main character.  Homer is an overweight, slob and a terrible father, but genuinely tries hard.

Homer previously had a job as safety inspector at Mr. Burns' Nuclear Power Plant, but good luck finding out what he's been doing for a living the last few years.

Homer Simpson Quotes

Homer: Aw, twenty dollars? I wanted a peanut!
Homer's Brain: Twenty dollars can buy many peanuts.
Homer: Explain how!
Homer's Brain: Money can be exchanged for goods and services.

You'll have to speak up, I'm wearing a towel.

Homer
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The Simpsons Quotes

Dearest Edna, I must leave you. Why, I cannot say. Where, you cannot know. How I will get there, I haven't decided yet. But one thing I can tell you, any time I hear the wind blow it will whisper the name Edna. And so let us part with a love that will echo through the ages. ---Woodrow

"Woodrow"

Homer: Aw, twenty dollars? I wanted a peanut!
Homer's Brain: Twenty dollars can buy many peanuts.
Homer: Explain how!
Homer's Brain: Money can be exchanged for goods and services.