Dr. Sheldon Cooper is Leonard's best friend, roommate, and co-worker at Calech. Sheldon is the smarter of the two with an IQ of 187, but is definitely the more socially awkward of two. He has a ridiculous ego, is extremely stubborn, but the group seems to put up with him.
It's very simple. Scissors cuts paper, paper covers rock, rock crushes lizard, lizard poisons Spock, Spock smashes scissors, scissors decapitates lizard, lizard eats paper, paper disproves Spock, Spock vaporizes rock, and, as it always has, rock crushes scissorsSheldon
Penny: I always tear up when the Grinch's heart grows three sizes.
Sheldon: Tears seem appropriate. Enlargement of the heart muscle, or hypertrophic cardiomyopathy, is a serious disease which can lead to congestive heart failure.