Bernadette: Well, what if Hulk picked up Thor while Thor is holding the hammer.
Amy: Yeah?
Bernadette: Then by the transitive property of picking things up Hulk picked up the hammer.
Amy: No. Hulk picked up Thor. Thor picked up the hammer.
Penny: Okay, hang on. If I go to a bar and pick up a guy and he picks up a girl and then we all leave together. Did I pick up the girl?
Amy: Did that ever happen?
Penny: Hey, are we talking about me or are we talking about Thor?

Sheldon: I read his research and ... it's leaps and bounds ahead of mine. Which means the mommy of the smartest physicist at the university is not my mommy as I thought. It's his mommy.
Amy: Sheldon, I wish there was something I could do to make you feel better. May I offer you a consoling hug?
Sheldon: What do we have to lose?
Amy: How's that?
Sheldon: I feel like I'm being strangled by a boa constrictor. Why did you stop?

Amy: Here I am?
Sheldon: Wait. Here who is where?

... cuz we out dropping science, son.

Then, what the hell, Sheldon!?!

A tumor would explain a lot.

Yeah, yeah, you want a cigarette. Well, I'd like a normal boyfriend. Deal with it.

Bernadette: We can't all be Cinderella.
Amy: Then, how do we decide?
Bernadette: Well, it's simple. This was my idea. I'm driving. I'm Cinderella. You bitches got a problem with that we can stop the car right now.

The world of science needs more women, but from an young age we girls are encouraged to care more about the way we look than the power of our minds.

Amy: Sheldon ... all Snow White needs is one small kiss to wake up.
Sheldon: Heard you the first time.

His quirks just make you love him more. ... Someone please agree with me.

Amy: Sheldon, I am not going through menopause.
Sheldon: Are you sure? You said that with the testy bark of an old bitty.

TBBT Quotes

Oh, Bernadette, please play my clarinet.

Raj's poem

Sheldon: I'll have a diet Coke.
Penny: Can you please order a cocktail? I need to practice mixing drinks.
Sheldon: Fine... I'll have a virgin Cuba Libre.
Penny: That's... rum and Coke without the rum.
Sheldon: Yes, and would you make it diet?