Bernadette: Doesn't he know you have a boyfriend?
Penny: Oh, she doesn't have a boyfriend; she has a Sheldon.

I'm too small for Twister. And, roller coasters. And sitting with my feet on the floor. Hope you enjoyed the prenatal cigarettes, Mom.

Oh, boo-hoo, you're not going to space!

Howard: You know, there's a saying we have at NASA. What makes the right stuff so right is that it always comes home.
Bernadette: Stop talking, Howard.

Bernadette: Are those Russian rockets safe?
Howard: Well, I mean, safe as it can be when it was build by the good folks who brought you Chernobyl.

Howard: Can you believe grown men sit around and play with toy trains?
Bernadette: That's pretty big talk for a man with a closet full of magic tricks at his mother's house.

Bernadette: I'm not going to live with your mother. Not now. Not ever.
Howard: Somebody, obviously, has some mommy issues.

Bernadette: I was head-hunted by a big pharmaceutical company. They're going to pay me a buttload of money!!
Leonard: Bernadette, that's great!! Howard, do YOU make a buttload?
Howard: Better than what YOU got a buttload of!

Bernadette: The thesis committee accepted my doctoral dissertation. I'm getting my Ph.D!!
(the other congratulate her)
Penny: Wow! So that means that....(points around the table to all the Ph.D's) You're a doctor, you're a doctor, you're a doctor, YOU'RE a doctor, and Howard....you know a lot of doctors!!

Howard's mother had a heart attack because I have sex with him and she can't!

I can't do this anymore. I'm a good girl! I went to Catholic School!

Some women don't like to get chummy when their panties are down.

TBBT Quotes

Oh, Bernadette, please play my clarinet.

Raj's poem

Sheldon: I'll have a diet Coke.
Penny: Can you please order a cocktail? I need to practice mixing drinks.
Sheldon: Fine... I'll have a virgin Cuba Libre.
Penny: That's... rum and Coke without the rum.
Sheldon: Yes, and would you make it diet?