Cop: You guys need me to call someone? I'm guessing your moms?
Leonard: Thanks, but we've got it covered.
Howard (walks up): Okay, I just talked to my mom.

Look, Leonard. There's a bridge. Drive off it.

Raj: I talk with my eyes.
Howard: You look like my little cousin when he's dropping one in his diaper.

Stuart: What's wrong with Christmas?
Sheldon: Where to begin? Trees indoors, overuse of the words "tis" and "twas," and the absurd custom of one stocking. Everyone notice socks belong in pairs. Who uses one sock?
Howard: A pirate with a peg leg.
Sheldon: Actually, that helps. Thank you.

Howard: You see, I have to play Dungeons and Dragons ... for the marriage.
Bernadette: You're an idiot.
Howard: I'm your idiot.

Sheldon: Is anyone else troubled by the Spider-Man theme song?
Leonard: Why would it trouble you? It's like your third favorite cartoon theme song.
Sheldon: It is, right behind [Sheldon sings "Inspector Gadget" and "Teenage Mutant Ninja Turtles" theme songs]
Sheldon: However, the Spider-Man lyrics posit that Spider-Man's Spider-Man does whatever a spider can.
Howard: Yeah, so?
Sheldon: I can think of many things that Spider-Man can't do that a spider can. One crawl in your ear and die, two legally leave Guatemala without a passport, and three have sex with a spider.

Howard: Boy, we're married to a couple of ball busters, huh, Mike?
Bernadette's Dad: That's my wife and daughter you're talking about.
Howard: Great couple of gals.
Bernadette's Dad: I wouldn't go that far.

Death by chicken. That's a pretty fowl way to go.

Howard: Well, we appear to have reached an impasse. And, you know, I have to say, I thought you'd be more upset that your laptop is sitting on my junk.
Raj: I didn't pick up on that. That's a nice touch.

Howard: Meanwhile, you still don't have a car.
Sheldon: Don't try to change the subject. This is about a parking space. It has nothing to do with cars.

Howard: Do you expect me to build this?
Sheldon: I expect you to wipe the pudding off your chin. Gentlemen.

Howard: Boy, if these walls could talk.
Leonard: They'd say, "Why does he touch himself so much?"
Howard: Yeah.

TBBT Quotes

Sheldon [to Kripke]: Also, I am given to understand that your mother is overweight.
Raj: Oh, snap.
Sheldon: Now of course, if that is the result of a glandular condition and not sloth and gluttony then I withdraw that comment.

How is "doable" anything but a compliment?

Wolowitz