Penny: What was Leonard like when he was little?
Mrs. Hofstadter: Oh, I think you mean "young." He's always been little.

Leonard [about his mother]: She's only been here a day and a half, and I'm seriously considering alcoholism as a new career path.
Penny: Hey, I talked to her for five minutes yesterday, and I've been half bombed ever since.

Penny: What are we gonna do?
Leonard: We? No, no, no. You had your chance to be "we" for like a year and a half now. Right now, you are you and you are screwed.

I'm from Nebraska. When we shoot things, it's because we want to eat em' or make them leave our boyfriends alone

Wolowitz [about his phone call]: Looks like I'm going to have sex tonight
Penny: His right hand is calling him?

Sheldon: I'm a physicist. I have a working knowledge of the entire universe and everything it contains
Penny: Who's Radiohead?
Sheldon [after twitching for a minute]: I have a working knowledge of the important things

Sheldon: You'll effectively be paying yor self 5.19 per day
Penny: A day??
Sheldon: There are children in sneaker factories in Indonesia that outearn you

Penny: It looks like the MySpace page of a 13 year old girl
Leonard: No it doesn't
Wolowitz: Oh please, Dateline could use it to attract predators

Wolowitz: According to Alicia's Facebook page, she's hooking up with one of the producers on CSI.
Penny: Dead whore on TV, live one in real life.

Penny [at comic book store]: Everyone's staring at me!
Leonard: Don't worry, they're more scared of you than you are of them
Penny: Unlikely

Penny [to comic book store owner]: What would you recommend as a gift for a 13 year old boy?
Stuart: A thirteen year old girl

Penny: I'm a Sagittarius, which probably tells you way more than you need to know.
Sheldon: Yes, it tells us that you participate in the mass cultural delusion that the sun's apparent position relative to arbitrarily defined constellations at the time of your birth somehow affects your personality.
Penny: Participate in the what?

TBBT Quotes

Oh, Bernadette, please play my clarinet.

Raj's poem

Sheldon: I'll have a diet Coke.
Penny: Can you please order a cocktail? I need to practice mixing drinks.
Sheldon: Fine... I'll have a virgin Cuba Libre.
Penny: That's... rum and Coke without the rum.
Sheldon: Yes, and would you make it diet?