What is it about that guy? Every time I see him, I get this weird itch. Like hives?

Coulson [to Simmons, about Ward]

I am fresh out of sympathy for liars who kidnapped my friends and replaced them with killer robots.

Simmons [to Radcliffe]

Simmons: You're not crazy!
Coulson: I live alone and make my own soap.
Simmons: It's quaint. Hipster, even!

Trust is a luxury these days.

Mace

Coulson: Got to say, the whole Rebel Alliance aesthetic is really working for me.
Mace: I'll take that as a compliment. I think.

It's me again. Phil Coulson. I called Hydra on you. My bad.

Coulson [to Simmons]

This reality may be upside down, but Fitz is still Fitz. He's a good person.

Simmons [to Daisy]

Madame Hydra: You'd really do anything for me, wouldn't you?
Fitz: I'd cross the universe for you.

Fitz: Treat this mole like a cancer.
May: I'll cut it out myself

Daisy: Wait, are you still dead?
Simmons: No, I'm feeling much better.

Student: Are Hydra all Nazis?
Simmons: Every last one of them. And don't you let anyone forget it.

Do you have moments where reality isn't quite right? Like your memories don't fit?

Simmons [to Coulson]

Agents of S.H.I.E.L.D. Quotes

Kasius: Yo-Yo Rodriguez? How peculiar.
Yo-Yo: Says the space mime!

Sousa: Hey, what are you doing up?
Daisy: Why do you care?
Sousa: Because you don't.