Nate: What, so you used me to get a story?
Charlie: The girl you're seeing is your boss?

Louis: The paternity test showed me that some part of you thought you might still have a choice to make, and I needed you to see that Chuck would always be the wrong one.
Blair: Louis, I don't now how many more times I can say this, but Chuck and I can never work.
Louis: You know that for certain?
Blair: I do. So does he. And so should you. Chuck destroys everything and everybody in his life. And he'll never change. But what's scaring me is that you're changing into him.

Don't worry, B. You're still marrying a Prince. Of Fools.

Dan: I was hoping we could talk more about the movie.
Jane: What movie. It's dead. If you want to know why, talk to your friend Serena.

Charlie: I'm starting to feel like I'm not Nate's type.
Penelope: Hello. Nate doesn't have a type. He's like Derek Jeter.

Diana: Jane and I have history. She doesn't always like to be reminded of it, but it's been awhile since I did.
Serena: What kind of history?
Diana: Some things are best left to the imagination. So, how bad do you want your problem to go away?

Serena: I gave Dan my word that I would protect him. He's one of my best friends. Please, don't do this to him.
Jane: It's already done. And you know what? I'm taking you off this project. Effective immediately. Like Dan you're just too close to it.

Jane: Did you already tell him we got Sorkin to write movie?
Dan: What? No. That's incredible.
Jane: I know. Now your character will talk even faster than you do.

Louis: How was your day?
Blair: Just what I needed. Old habits die hard.
Louis: If they die at all.

When you drive Chuck over the edge, it's you who will wind up road kill.

Gossip Girl: Spotted: S trying to navigate a slippery slope. But she's not the only accident waiting to happen.

Jane: Inside will be the next Social Network. We're gonna Zuckerberg him.
Serena: Jane, this is unfair.
Jane: I prefer to let the audience decide what's fair or not.
Serena: Dan is not like that. Why don't I put a dinner on the books for all of us and this way you'll see.
Jane: The next time I see Dan will be at Cannes when I'm shaking his grateful hand on the dais.

Gossip Girl Quotes

Even Blair Waldorf can not bend DNA to her will.

Dan

Hazel: Do you know what you're doing, Little J?
Jenny: I'm not Little J anymore.