Serena: What was Dan's big surprise?
Blair: It was more of an ambush. He got into this writing program in Rome and he wants me to go with him the entire summer.
Serena: How dare he! Blair, that's amazing.
Blair: I told him I had to check my calendar to buy some time to think.
Serena: What's there to think about? Rome for the summer sounds like a dream.
Blair: Not for Romans. The whole place will be crawling with Americans.
Serena: And you can be two of them.
Blair: But it's a big decision. And spending last summer at Louis' side I was hoping to do my own thing.
Serena: So your indecision has nothing to do with Chuck?
Blair: Absolutely not. My concern for him at this time is about something entirely unrelated.
Serena: Which you can't tell me about. B, I hate being out of the loop.

Diana: I don't suppose you came here to thank me.
Chuck: Thank you for what? Not telling me my father was alive, pretending to be my mother, or screwing my best friend?
Diana: You mean for keeping your father alive. Pretending to be your mother to protect him and, well, I don't expect you to thank me for Nate. Perhaps I should thank you for that one.
Chuck: Look, I'm not here to hug it out or bond over my father's resurrection. I just need your help in keeping him here.
Diana: I'm afraid that's not possible.
Chuck: I'm afraid it is. You've been helping him hide. I think you know who from. Who tried to kill my father? I know it was one of his competitors, someone powerful enough to scare him into hiding these last few years. I just want a name.

Blair: I'm with Chuck.
Serena: B.
Blair: No it's not like that. He needs me. He's going through an extremely difficult time right now.
Serena: Yeah, of course he is. Especially if it means taking you away from Dan to be with him. And you just told me Dan is having trust issues.
Blair: I know, but this is life or death.

But the best way to avoid giving an answer is to avoid the question all together.

Blair: Chuck, I can't really be seen with you right now. But how are you doing? Are you okay?
Chuck: Far from it. I have to find a way to stop my father from leaving tonight.
Blair: Leaving? But you just found him.
Chuck: He left to keep me safe. Now it's my turn to save him.

Sometimes looking for answers only leads to more questions. And sometimes you're better off not knowing.

Chuck: There's so much I want to know. I guess now we have time. You can tell me everything.
Bart: Unfortunately I'm afraid our time is up. If the man I'm hiding from were to discover I'm still alive he'd try and kill me again. Or go after you.
Chuck: Let's go after him.
Bart: All you need to know is that as long as I'm still around we're still in danger.

Serena: When Georgina left town she gave me her laptop and it had a direct link to the Gossip Girl server, passwords, the software, everything.
Blair: S, you had me at Georgina, but I can't believe it. Why didn't you tell me?
Serena: I don't know. I felt like it was something I had to keep secret from everyone. I mean, my best friend even. I know it was wrong and I'm so sorry.
Blair: I mean I could have helped. Sealing fates, forging destinies. Like an imperious Greek goddess. Imposing her will on the guileless masses. But I was wondering why Gossip Girl was being so nice to me lately. And a little off her game. No offense.
Serena: So you're not mad?
Blair: I am furious with you! For not sharing your good fortune and omnipotence. But right now I have to go replace my mother's La Mer before she returns from Paris and discovers I've used it all.

Blair: I mean the most important thing in a relationship is trust. After sex. And hygiene. And earning potential. Wait. What did you think I was going to say?
Serena: Ah... I mean, it's not important. Nowhere near as important as Dan and Italy and his trust issues. We should get coffee and you should tell me more about it.
Blair: Wait. Okay, using a very generous grading curve and rounding up—because I like your outfit—that lie was a C+ at best. What is going on?
Serena: Something I've been wanting to talk to you about for awhile now. I've been posting on Gossip Girl as Gossip Girl. For a couple of months now.

Blair: Guess what I found out this morning?
Serena: B, I know what you're going to say. But first I really want to tell you—
Blair: Dan turned down the opportunity to spend the summer in Rome with the world's literary luminaries. And do you know why? Because he's scared of leaving me here with Chuck. Can you believe it?
Serena: Sort of.

Nate: I want you out of here. Today.
Diana: After all the fun we've had together?
Nate: What would people think if they knew about your side business?
Diana: Is that a threat? Because I am your main financial backer and we did sleep together. Sometimes right here in these very offices. So exposing me would only embarrass The Spectator. And you.
Nate: Then I'll find another way.

Blair: That was your agent. She wants you to reconsider the program in Rome. Which is odd, because you told me they went with someone else.
Dan: Ah, well, yesterday when you ended up with Chuck I was a little nervous about leaving for the whole summer. And I know you told me there were other people there and it was not romantic, but... come on. It's Chuck.
Blair: So you lied to me.
Dan: I figured you would just think I was some jealous freak if I told the truth.
Blair: Well maybe because you are. But you don't have to be. You have nothing to worry about. Take the offer. It's an amazing opportunity and I would never stand in the way of it.
Dan: It means the entire summer apart.
Blair: But it's not like I can't come visit. Rome is just two glasses of chardonnay away.

Gossip Girl Quotes

Even Blair Waldorf can not bend DNA to her will.

Dan

Hazel: Do you know what you're doing, Little J?
Jenny: I'm not Little J anymore.