Ian: Hey Fiona? I'm gay.
Fiona: I know.

We’re all addicts Fiona, trying to fill a void. Some of us are just better at hiding it, right?

Robbie

When you're poor, the only way to make money is to steal it or scam it.

Lip

The best gift you can give is neglect. Neglect fosters self-reliance.

Frank [to Lip]

Sean: You took your monitor off yourself.
Fiona: So?
Sean: So, you should have waited for the P.O. and you know it.
Fiona: That's a technicality. You're gonna judge me for that?
Sean: No, I'm not gonna judge you for that. I find it charming as fuck that you took a screwdriver to your monitor. And I find it sexy as hell that you had a bloody lip before lunch today.
Fiona: Are you making fun of me?
Sean: No. It's just you're a chaos junkie, Fiona. And I'm a junkie, junkie. So I love chaos. And when I get into chaos, bad shit follows.

Where can I get knives and blunts?

Debbie

Get your ass up you goddamn ponytail Fabio motherfucker.

Sheila

She was born with a large clitoris!

Frank

I also danced with Cab Calloway, he had the first colored penis I ever kissed.

Fake Aunt Ginger

Holy shit, you popped his cherry? And how was the 30 seconds of bliss.

Veronica

Oh don't mind me, I accidentally took three of my pills instead of one.

Sheila

Frank: Beautiful day for a party!
Neighbors: It's for kids, Frank. No booze!

Shameless Quotes

Ian: Hey Fiona? I'm gay.
Fiona: I know.

We’re all addicts Fiona, trying to fill a void. Some of us are just better at hiding it, right?

Robbie