Dean: You know what I will have that other one [drink].
Bartender: I thought you were working?
Dean: I'm working up to it.

Castiel: It isn't the Horn of Truth.
Dean: What are you talking about? You were gone for like two seconds. Where did you look?
Castiel: Everywhere.

Dean: Are you kidding me? I have been on red alert about Sam and you come for some stupid horn?
Castiel: You asked me to be here and I came.
Dean: I've been asking you for days you d**k!

Bobby: There's a worse case scenario.
Dean: What? Saying he's my co-pilot? Yeah, I know.
Bobby: No, that'd be the other worst case.
Dean: Then what?
Bobby: Maybe it's just Sam.

These aren't vampires, man. These are douche bags.

Dean

I'm ok. I killed so many people on the way over here.

Dean

Dean: Newsflash Mr. Wizard: "vampires pee."

Dean: Are you wearing glitter?
Kid: I only do it to get laid, man.
Dean: Does it work?

You go with Efron. I've got Bieber.

Dean

Dean: Try uh, Lautner.
Sam: He's a werewolf. How do you even know who that is?
Dean: What are you kidding me? That kid is everywhere. It's a friggen nightmare.

Look at this. Watching her sleep, how is that not rape-y?

Dean

Bobby: Ok then, lets roll credits on this chick flick. You boys have a safe flight and uh, try some of the local grub. I hear it's exotic.
Dean: Oh yeah, no, definitely, we are. I hear they have an Olive Garden.

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean