Castiel: This creature has the power to take a human's form, read minds. Book of Revelations call her the "Whore of Babylon."
Dean: Well, that's catchy.

Sam: What's wrong with you? Are you... drunk?
Castiel: No! Yes.
Sam: What the hell happened to you.
Castiel: I found a liquor store.
Sam: And?
Castiel: I drank it.

Dean: 'Course, that's if you can get past the velvet rope. Must be nice--being chosen.
Leah: Well, Dean... you're chosen.
Dean: More like cursed.

No drinking, no gambling, no pre-marital sex. Dean, they basically just outlawed 90% of your personality.

Sam

The worst was the smell. The pain, well... what can you say about your skin bubbling off? But the smell was so... You know, for a second, I thought I left a pot roast burning in the oven. But.. it was my meat. And then, finally, I was dead.

Mary

See, you got to stop thinking of Heaven as one place. It's more like a buttload of places. All crammed together. Like Disneyland. Except without all the anti-Semitism.

Ash

Wow. Running from angels... on foot... in Heaven. With out-of-the-box thinking like that, I'm surprised you boys haven't stopped the Apocalypse already.

Zachariah

Sam: Dad said they always had the perfect marriage.
Dean: It wasn't perfect until after (Mary) died.

Sam: Heaven?
Dean: Yeah.
Sam: Okay, how are we in Heaven?
Dean: All that clean living, I guess.

Go ahead, Roy. Do it. But I'm gonna warn you--when I come back, I'm gonna be pissed.

Dean

What are you, the Hamburglar?

Dean

Why does Heaven care if Harry meets Sally?

Dean

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean