Dean: What exactly are we gonna march up there and tell 'em?
Sam: Uh, the truth.
Dean: What, that their sons are back from the future to save them from an angel gone Terminator? Come on, those movies haven't even come out yet.

Dean: Really? Anna?
Castiel: It's true.
Dean: So she's gone all Glenn Close, huh? That's awesome.
Castiel: Who's Glenn Close?
Dean: No one. Just this psycho bitch who likes to boil rabbits.
Sam: So, the... the plan to kill me--would it actually stop Satan?
Dean: No, Sam, come on.
Sam: Cass, what do you think? Does Anna have a point?
Castiel: No. She's a... "Glenn Close."

Sam: You still crazy?
Dean: Not any more than usual.

Dr. Cartwright: Why you?
Dean: Why me what?
Dr. Cartwright: Why do you have to hunt monsters? Why not let someone else do it?
Dean: I can't find anybody else that dumb.

Dr. Cartwright: I'm Dr. Erica Cartwright. I've been assigned to your case.
Dean: You're my shrink? Well, lucky me.
Dr. Cartwright: And you're my paranoid schizophrenic with narcissistic personality disorder and religious psychosis. Lucky me.

Dr. Fuller: You were referred to me by a Dr. Baber in Chicago.
Dean: That's right.
Dr. Fuller: Isn't there a children's book about an elephant?
Dean: I don't know. I don't have any elephant books.

Sam: Okay, last words?
Dean: I think I'm good.
Sam: Yeah, me too.
Dean: Here goes nothing.

Lucifer: Castiel, right? Castiel. I'm told you came here in an automobile.
Castiel: Yes.
Lucifer: What was that like?
Castiel: Um, slow. Confining.
Lucifer: What a peculiar thing you are.

Dean: Okay, and why exactly would you want the Devil dead?
Crowley: It's called survival. But I forgot you two are at best functioning morons.
Dean: You're a functioning... morons... moron.

Sam: Oh, hey, Chuck, look. If you really want to publish more books, I guess that's okay with us.
Chuck: Wow. Really?
Sam: No, not really. We have guns and we will find you.

Look, Sam, I'm not going to lie. We had undeniable chemistry. But like a monkey on the sun, it was too hot to live.

Becky

Uh, no, there's really no such thing as a Croatoan Virus for... down there. You really should see a doctor.

Chuck

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean