Sam: Let’s pick up a six-pack.
Dean: Just six?

Sleeping is the new smoking.

Dean

He who hesitates, disintegrates.

Lucifer

Apparently archangel plus God power doesn’t trump God’s sister.

Sam

This is exactly how we screw ourselves. We make the heart choice instead of the smart choice.

Sam

I'm going to come back for you. OK? I promise.

Dean

Game’s over, Dean. No more second chances. No more extra lives. Time to say bye bye to Luigi, Mario.

Billie

I told you that roadhouse chili was a bad idea.

Sam

You can't save everyone.

Rufus

I'm worried about my boys.

Bobby

Bobby: Were you ever nice?
Rufus: 1985. Worst year of my life.

You really thought you could double-cross me? Me? You know, I invented the double-cross. Like, literally.

Lucifer

Supernatural Quotes

You betrayed me? No one in the history of torture's been tortured with torture like the torture you'll be tortured with.

Crowley

Endings are hard. Any chapped-ass monkey with a keyboard can poop out a beginning, but endings are impossible. You try to tie up every loose end, but you never can. The fans are always gonna bitch. There's always gonna be holes. And since it's the ending, it's all supposed to add up to something. I'm telling you, they're a raging pain in the ass.

Chuck