We're on our third "the world is screwed" issue in what three years?

Dean

Well, Motel 6 just ain't leaving the light on anymore.

Sam

I think it's reasonable to want to know that you're off the freaking high dive, Sam. You almost got us both killed. So you can be pissed all you want, but quit being a bitch.

Dean

If you affirmate me, I'm gonna punch you in the face.

Dean

Ugh, I can't believe he was boning her.

Dean

Jimmy Tomorrow: You're looking... for something.
Dean: You're good.

Waiter: You are a virile manifestation of the divine.
Dean: What the hell did he say to me?

Dean: It's kind of like, Bewitched, you know? Don's Darren and doesn't even know it. Lot of laughs until you cheat on your wife.
Sam: Bewitched reference. Really?
Dean: Dude, Nicole Kidman was in the remake. Red head. Hello.

Don: She bakes cupcakes.
Dean: Yummy.

Sam: Really? From a freaking flask? What are you Bad Santa? On the job?
Dean: We're always on the job.

Dean: While you were out being Lance Armstrong...
Sam: That would be biking.

Nothing in our lives is simple.

Sam

Supernatural Quotes

Why do they call this place The Empty? It's full. It's full of sorrow and despair playing over and over again of angels and demons dreaming about their regrets. Forever.

Ruby

Weird, creepy, off-the-grid "Children of the Corn" people? Yeah, I’m in.

Dean