Damon and Stefan Salvatore
The Vampire Diaries is a love story, it's true. But it's really a love story between Damon and Stefan Salvatore.
Klaus and Elijah Mikaelson
Klaus and Elijah have been through it all over 1,000 years on The Originals. This is an ever-evolving relationship.
Derek and Amelia Shepherd
Two good looking, successful doctors? The Shepherd parents sure did something right.
Tyrion, Cersei and Jaime Lannister win the award for Most Dysfunctional Siblings in the History of Television.
Oliver and Thea Queen
He may be concerned about fighting crime and righting wrongs, but nothing will ever be more important to Oliver Queen than the well-being of his sister.
Claire and Mitchell
She isn't a Pritchett any longer, but as this Modern Family photo makes clear, the brother-sister bond remains.
Sam and Dean Winchester
The bond between Sam and Dean Winchester is what drives all of Supernatural.
Edith and Mary Crawley
Having lost one sister, Edith and Mary Crawley need each other more than ever on Downton Abbey.
Daniel and Charlotte Grayson
Sometimes, for Daniel and Charlotte Grayson on Revenge, the duplicitious apples don't fall far from the very mean trees.
Sookie and Jason Stackhouse
Through blood, death, violence and A LOT of nudity, Sookie and Jason Stackhouse have remained tight on True Blood.
Michael, Job and Buster Bluth represent the funniest siblings on television. We will not accept any alternatives.
Stewie may never want to admit it, but he IS related to Meg and Chris on Family Guy.
They never age on The Simpsons, but Bart, Lisa and Maggie never fail to elicit laughter either.
Jenny and Abbie Mills
They hadn't seen each other in years. But Jenny and Abbie Mills were very much on the same team by the end of Sleepy Hollow Season 1.
Dennis and Dee Reynolds
The brother and sister who get wasted together and lack morals together stay together. Right, Dennis and Dee Reynolds?
Evan and Hank Lawson
Hank and Evan shouldn't always mix business with their personal lives on Royal Pains. But it typically works out in the end.
The Clone Club
Can we refer to Sarah Manning and all her clones on Orphan Black as "sisters?" We're just gonna go ahead and do so.