Hank has a reason to be skeptical in this scene. He's meeting the actor set to play him on the big screen.
Rob Lowe recurs on season four of Californication. He plays an actor named Eddie Nero.

Californication Season 4 Episode 2 Quotes

Fuck you, you fucking pedophile what's so gross about fucking me?


Hank: No Charlie you look good. Like a baby. Like a big sexy baby.
Charlie: Thank you.