Hank has a reason to be skeptical in this scene. He's meeting the actor set to play him on the big screen.
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Rob Lowe recurs on season four of Californication. He plays an actor named Eddie Nero.
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Californication Season 4 Episode 2 Quotes

Fuck you, you fucking pedophile what's so gross about fucking me?

Marci

Hank: No Charlie you look good. Like a baby. Like a big sexy baby.
Charlie: Thank you.