When Peter goes back in time and messes things up with Lois, she ends up marrying Quagmire and having a Chris, Meg and Stewie that look like Quagmire instead.
Added:
Lois runs against Adam West for Mayor of Quahog and ends up winning.
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Whenever Family Guy needs a B story, you can always expect the chicken to return to fight Peter.
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When forced to run to Texas and dress as a girl, Stewie enters a Little Miss Texas Pageant.
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Peter ends up opening a restaurant on Family Guy and Joe's friends quickly populate it.
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After Peter fixes Bill Clinton's flat tire, the two of them become best friends on Family Guy.
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Hugh Hefner swings by Family Guy to give Quagmire some advice after he loses his job.
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After going outside without sunscreen, Stewie becomes obsessed with tanning.
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Family Guy Season 5 Quotes

(Brian and Stewie sitting at table)Brian: So what happened?Stewie: Well, you wanna know what I learned this week? Being a grown-up sucks. Women, Brian...what a royal pain in the ass. It's like, it's like, why can't you just hang out with guys, you know? Just live with someone of your own sex. Just do what you would do with women, but with your buddy, you know? Why don't guys just do that?Brian: They do, it's called being gay.Stewie: Oh, that's what gay is? Oh yeah, I could totally get into that.

Stewie: Spit on me.
(Brian spits on him)
Stewie: (sighs) That's nice. Now tell me I'm scum.
Brian: How will that cool you off?
Stewie: Hmmm?